Biochemical alterations induced by nickel oxide nanoparticles in female Wistar albino rats after acute oral exposure |
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| Authors: | Naresh Dumala Bhanuramya Mangalampalli Sarika Srinivas Kalyan Kamal |
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| Institution: | 1. Toxicology Unit, Pharmacology and Toxicology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India;2. Academy of Scientific and Innovative Research, CSIR-Indian Institute of Chemical Technology, Hyderabad, India;3. Analytical Chemistry Division, Defence Metallurgical Research Laboratory, Hyderabad, India |
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| Abstract: | Context: Nickel oxide (NiO) nanoparticles (NPs) with appropriate surface chemistry have been widely used for their potential new applications in biomedical industry. Increased usage of these NPs enhances the chance of exposure of personnel involved in the work place.Objective: This study was designed to assess the ability of NiO NPs to cause biochemical alterations post-acute oral exposure in female Wistar rats.Materials and methods: Rats were administered with 125, 250, and 500?mg/kg doses of NiO NPs for haematological, biochemical, and histopathological studies. Biodistribution patterns of NiO NPs in female Wistar rats were also monitored.Results: NiO NPs caused significant (p?Conclusions: This study revealed that exposure to nanosized NiO particles at acute doses may cause adverse changes in animal biochemical profiles. Further, the in vivo studies on toxicity evaluation help in biomonitoring of the potential contaminants. |
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| Keywords: | Nickel oxide nanoparticles biochemical alterations haematology oxidative stress |
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