Assignment of Human Membrane-type Matrix Metalloproteinase-2 (MT2-MMP) Gene to 16q12 by FISH and PCR-based Human/Rodent Cell Hybrid Mapping Panel Analysis |
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| Authors: | Yasumitsu Hidetaro; Shofuda Ken-ich; Nishihashi Ai; Eki Toshihiko; Koshikawa Naohiko; Mizushima Hiroto; Miyazaki Kaoru |
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| Institution: | 1Division of Cell Biology, Kihara Institute for Biological Research, Yokohama City University 641-12 Maioka-cho, Totsuka-ku, Yokohama 244, Japan
2Cellular Physiology Laboratory and Gene Function Research Group, Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN) 3-1-1 Koyadai, Tsukuba Science City, Ibaraki 305, Japan |
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| Abstract: | A new group of matrixmetalloproteinase with a potential membranedomain was reported as membranetype matrixmetalloproteinases(MT-MMPs), and the gene coding for one of them, MT2-MMP, wasrecently cloned from a human lung cDNA library. To predict itsphysiological functions by the relation to the genetic disordersmapped on the chromosomes, the chromosomal location of the humanMT2-MMP gene was examined by fluorescence in situ hybridization(FISH) and PCR-based analysis with human/rodent hybrid cellmapping panels, and it was assigned to 16q12. |
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