The cAMP content and cAMP-dependent protein kinase activity in the brain of rabbits in the dynamics of moderate craniocerebral trauma |
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Authors: | S N Kucherenko L I Ostapenko A N Vasil'ev |
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Abstract: | An intracellular concentration of cAMP is a factor to define activity of cAMP-dependent protein kinases. Enzyme activity changes in cytosol and microsomal fractions from investigated brain's regions. Two-phase character of posttraumatic changes of A-kinases activity is shown. Linear dependence for microsomal fractions obtained from brain's hemispheres is observed between A-kinases activity and calculated equilibrium cAMP concentration in different time after experimental cranial trauma. |
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