Interaction of alpha 2-macroglobulin-bound thrombin with hirudin |
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| Authors: | F Pochon M Steinbuch |
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| Affiliation: | 1. U.219 INSERM, Institut Curie - Biologie, Campus Universitaire, 91405 OrsayFrance;2. Centre National de Transfusion Sanguine, 91400 Orsay, France |
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| Abstract: | The human thrombin bound to alpha 2-macroglobulin (alpha 2 M) in a 1:1 stoichiometry is still able to interact with one of its specific inhibitors, hirudin. The dissociation constant of the complex hirudin--alpha 2M-bound thrombin is 1 X 10(-7) M, whatever the mode of thrombin binding, covalent or non-covalent. |
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| Keywords: | Thrombin Hirudin |
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