A novel translocation,t(9;21)(q13;q22) rearranging the RUNX1 gene in acute myelomonocytic leukemia |
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Authors: | Paulien Sylvie Maarek Odile Daniel Marie Thérèse Berger Roland |
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Institution: | Institut de biologie et biochimie appliquée (IBBA), université de Caen, esplanade de la Paix, 14032 cedex, Caen, France. |
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Abstract: | A novel translocation t(9;21)(q13;q22) associated with trisomy 4 has been detected in a patient with acute myelomonocytic leukemia (AML,M4) in relapse. The chromosomal translocation results in rearrangement of the RUNX1 gene at 21q22. The DNA sequence rearranged on chromosome 9 remains unidentified. The diversity of the partners involved in translocations implicating RUNX1 suggests that the functional consequences of the abnormality are more due to the truncation of RUNX1 than to the identity of its partner in the rearrangement. |
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Keywords: | AML-M4 RUNX1 gene Translocation t(9 21) |
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