L-serine dehydratase and L-serine-pyruvate aminotransferase activities in different animal species. |
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Authors: | E V Rowsell J A Carnie S D Wahbi A H Al-Tai K V Rowsell |
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Affiliation: | Department of Biochemistry, University of Manchester, Institute of Science and Technology, England. |
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Abstract: | 1. A rough inverse correlation between liver serine dehydratase activity and species body size was observed with mammals. This was not found for glutamate, malate or lactate dehydrogenase, fumarase or aspartate-2-oxoglutarate aminotransferase. Serine dehydratase (and certain liver aminotransferases showing a similar species-size dependence) may have a role in the stimulation of heat production. 2. Cold-exposed rats showed a 3-4 fold increase in serine dehydratase activity. 3. No liver serine dehydratase was measurable in amphibia. 4. In mammals high liver serine-pyruvate aminotransferase is associated with a flesh-eating dietary habit. High activity was found in amphibia and goldfish. A gluconeogenic role is suggested. |
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