Genome-based analysis of pneumococcal virulence factors: the quest for novel vaccine antigens and drug targets |
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| Authors: | Paton J C Giammarinaro P |
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| Affiliation: | 1. Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453, USA;1. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;2. University of Chinese Academy of Sciences, Beijing 100039, China |
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| Abstract: | Efforts to develop cheaper and more effective vaccines against Streptococcus pneumoniae have been greatly facilitated by access to the genome sequence for this organism. Targeted searches of the genome sequence, as well as techniques to identify genes essential for survival of the pathogen in vivo, have yielded promising new candidate vaccine antigens. |
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