Interaction of the molecular chaperone HtpG with uroporphyrinogen decarboxylase in the cyanobacterium Synechococcus elongatus PCC 7942 |
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| Authors: | Saito Masakazu Watanabe Satoru Yoshikawa Hirofumi Nakamoto Hitoshi |
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| Affiliation: | Department of Biochemistry and Molecular Biology, Saitama University, Japan. |
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| Abstract: | Uroporphyrinogen decarboxylase (HemE) is important due to its location at the first branch-point in tetrapyrrole biosynthesis. We detected a complex formation between full-length polypeptides of HtpG and HemE by biochemical studies in vivo and in vitro. The interaction suppressed the enzyme activity, suggesting a regulatory role of HtpG in tetrapyrrole biosynthesis. |
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