Enkephalin, substance P, and serotonin axonal input to c-fos-like immunoreactive neurons of the rat spinal cord |
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Authors: | S Pretel and D T Piekut |
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Institution: | University of Rochester, School of Medicine and Dentistry, Neuroendocrine Unit Box 609, 601 Elmwood Avenue, Rochester, NY 14642, USA |
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Abstract: | Mustard oil, which stimulates small diameter afferents, was used to evoke the expression of the oncogene c-fos in the lumbar spinal cord. C-fos-like immunoreactivity was concentrated in, but not limited to, neuronal nuclei of laminae I and II of the lumbar dorsal horn. Double-label immunocytochemistry was used to determine if neurons which expressed c-fos-like immunoreactivity received axonal input from enkephalin-, substance P- or serotonin-immunoreactive neurons. The analysis of vibratome and semithin plastic-embedded tissue sections demonstrated that the majority of c-fos-like immunoreactive neurons received input from enkephalin-, substance P- or serotonin-immunoreactive axonal varicosities. |
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Keywords: | Immunohistochemistry Double-label Nociception Oncogenes Neurotransmitters |
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