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Delayed type hypersensitivity responses to radiation leukemia virus variants |
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| Authors: | G Strassmann N Haran-Ghera |
| Institution: | Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel |
| Abstract: | DTH responses were evaluated in different strains of mice shown to be resistant or sensitive to leukemogenesis by the radiation leukemia virus variants A-RadLV and D-RadLV. A significant response was observed only in the H-2 complex-linked resistant haplotypes to RadLV leukemogenesis. The DTH response could be transferred by immune cells of mice resistant to the appropriate RadLV variant. Thus, an inverse relationship between the leukemogenic activity of the virus and its immunization ability expressed by DTH response was demonstrated in different mouse strains. |
| Keywords: | To whom correspondence should be addressed Department of Clinical Immunology and Biological Therapy M D Anderson Hospital and Tumor Institute 6723 Bertner Ave Houston Tex 77030 |
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