Aggregation of amphiphilic pullulan derivatives evidenced by on-line flow field flow fractionation/multi-angle laser light scattering |
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| Affiliation: | 1. University of Tunis, Preparatory Institute for Engineering Studies of Tunis, Materials and fluids laboratory, Tunisia;2. Department of Physics, University of Zabol, Zabol, P. O. Box. 35856-98613, Islamic Republic of Iran;1. Department of Pharmacodynamics, Chair of Pharmacodynamics, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland;2. Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland;3. Department of Fundamental Engineering, Faculty of Production Engineering, Warsaw University of Life Sciences, Nowoursynowska 164, 02-787 Warsaw, Poland;4. Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland |
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| Abstract: | Size-exclusion chromatography (SEC) is a useful steric separation technique for the analysis of water-soluble polysaccharides in aqueous solution. However, in the case of amphiphilic derivatives, the usefulness is limited because of interactions between hydrophobic segments and the stationary phase. Alkyl-bearing pullulans differing from the extent and the length of alkyl groups were characterized using flow-field flow fractionation with on-line coupling multi-angle laser light scattering (F4/MALLS). Comparison of SEC and F4 is presented and the interest of F4 in the field of amphiphilic derivatives is demonstrated. |
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