Synthesis of tetracontapeptide--a hypothetical evolutionary precursor of calcium-binding proteins. I. Synthesis of (1-9), (10-14), (15-20), (21-26), (29-33), (34-40) fragments |
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Authors: | V S Grechishko V N Medvedkin N P Zapevalova R Jung Iu V Mitin |
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Abstract: | Fragments (1-9), (10-14), (15-20), (21-26), (29-33) and (34-40) of a tetracontapeptide hypothetical ancestor of calcium-binding proteins were synthesised with the use of pentafluorophenyl esters. Formation of a succinimide derivative was detected during synthesis of fragment (15-20) containing Asp(OBzl)-Gly sequence. To avoid this side process, tert-butylprotecting group was used instead of benzyl group. alpha-Carboxyls of C-terminal amino acids were protected by phenacyl group. |
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