Genotype networks,innovation, and robustness in sulfur metabolism |
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Authors: | João F Matias Rodrigues Andreas Wagner |
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Institution: | (1) Institute of Evolutionary Biology and Environmental Studies Bldg. Y27, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland;(2) The Santa Fe Institute, 1399 Hyde Park Road, 87505 Santa Fe, New Mexico, USA;(3) The Swiss Institute of Bioinformatics, Quartier Sorge, CH-1015 Lausanne-Dorigny, Switzerland |
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Abstract: | Background A metabolism is a complex network of chemical reactions. This network synthesizes multiple small precursor molecules of biomass
from chemicals that occur in the environment. The metabolic network of any one organism is encoded by a metabolic genotype,
defined as the set of enzyme-coding genes whose products catalyze the network's reactions. Each metabolic genotype has a metabolic
phenotype. We define this metabolic phenotype as the spectrum of different sources of a chemical element that a metabolism
can use to synthesize biomass. We here focus on the element sulfur. We study properties of the space of all possible metabolic
genotypes in sulfur metabolism by analyzing random metabolic genotypes that are viable on different numbers of sulfur sources. |
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