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Interactions among oscillatory pathways in NF-kappa B signaling |
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| Authors: | Yunjiao Wang Pawel Paszek Caroline A Horton Douglas B Kell Michael RH White David S Broomhead Mark R Muldoon |
| Affiliation: | (1) Mathematical Biosciences Institute, The Ohio State University, Jennings Hall, Columbus, Ohio 43210, USA;(2) Centre for Cell Imaging, School of Biological Sciences, Bioscience Research Building, Crown Street, Liverpool, L69 7ZB, UK;(3) School of Chemistry and The Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK;(4) School of Mathematics, Alan Turing Building, University of Manchester, Manchester, M13 9PL, UK |
| Abstract: | BackgroundSustained stimulation with tumour necrosis factor alpha (TNF-alpha) induces substantial oscillations—observed at both the single cell and population levels—in the nuclear factor kappa B (NF-kappa B) system. Although the mechanism has not yet been elucidated fully, a core system has been identified consisting of a negative feedback loop involving NF-kappa B (RelA:p50 hetero-dimer) and its inhibitor I-kappa B-alpha. Many authors have suggested that this core oscillator should couple to other oscillatory pathways. |
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