Macrophage colony-stimulating factor and its receptor signaling augment glycated albumin-induced retinal microglial inflammation in vitro |
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| Authors: | Wei Liu Ge Z Xu Chun H Jiang Jie Tian |
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| Affiliation: | (1) Department of Opthalmology, EENT Hospital, Eye Institute, Fudan University, 200031 Shanghai, China;(2) Institute of Brain Science, Fudan University, 200031 Shanghai, China |
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| Abstract: | Background Microglial activation and the proinflammatory response are controlled by a complex regulatory network. Among the various candidates, macrophage colony-stimulating factor (M-CSF) is considered an important cytokine. The up-regulation of M-CSF and its receptor CSF-1R has been reported in brain disease, as well as in diabetic complications; however, the mechanism is unclear. An elevated level of glycated albumin (GA) is a characteristic of diabetes; thus, it may be involved in monocyte/macrophage-associated diabetic complications. |
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