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HIV-1 infected monozygotic twins: a tale of two outcomes
Authors:Loubna Tazi   Hiromi Imamichi   Steven Hirschfeld   Julia A Metcalf   Susan Orsega   Marcos Pérez-Losada   David Posada   H Clifford Lane  Keith A Crandall
Abstract:

Background  

Replicate experiments are often difficult to find in evolutionary biology, as this field is inherently an historical science. However, viruses, bacteria and phages provide opportunities to study evolution in both natural and experimental contexts, due to their accelerated rates of evolution and short generation times. Here we investigate HIV-1 evolution by using a natural model represented by monozygotic twins infected synchronically at birth with an HIV-1 population from a shared blood transfusion source. We explore the evolutionary processes and population dynamics that shape viral diversity of HIV in these monozygotic twins.
Keywords:
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