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A 6-gene signature identifies four molecular subgroups of neuroblastoma
Authors:Email author" target="_blank">Frida?AbelEmail author  Daniel?Dalevi  Maria?Nethander  Rebecka?J?rnsten  Katleen?De Preter  Jo?lle?Vermeulen  Raymond?Stallings  Per?Kogner  John?Maris  Staffan?Nilsson
Institution:(1) Department of Clinical Genetics, Gothenburg University, Gothenburg, Sweden;(2) Department of Mathematical Statistics, Chalmers University of Technology, Gothenburg, Sweden;(3) Genomics Core Facility, Gothenburg University, Gothenburg, Sweden;(4) Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium;(5) Department of Cancer Genetics, Royal College of Surgeons in Ireland and Children’s Research Centre, Our Lady’s Children’s Hospital, Dublin, Ireland;(6) Childhood Cancer Research Unit, Karolinska Institute, Astrid Lindgren Children’s Hospital, Q6:05, S-171 76, Stockholm, Sweden;(7) Children’s Hospital of Philadelphia, Division of Oncology, The University of Pennsylvania, Philadelphia, PA, Philadelphia
Abstract:

Background  

There are currently three postulated genomic subtypes of the childhood tumour neuroblastoma (NB); Type 1, Type 2A, and Type 2B. The most aggressive forms of NB are characterized by amplification of the oncogene MYCN (MNA) and low expression of the favourable marker NTRK1. Recently, mutations or high expression of the familial predisposition gene Anaplastic Lymphoma Kinase (ALK) was associated to unfavourable biology of sporadic NB. Also, various other genes have been linked to NB pathogenesis.
Keywords:
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