Susceptibility to fluconazole and amphotericin B in clinical Candida isolates. |
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Authors: | Martínez J Albrecht C |
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Institution: | Hospital Nacional de Clínicas, Laboratorio Central, División Micología, Córdoba, Argentina. |
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Abstract: | Susceptibility to fluconazole and amphotericin B in 84 clinical isolates of Candida was determined by a macrodilution method (NCCLS). Amphotericin B was very active (CMI < 1.25 microg/ml) against C. tropicalis and C. parapsilosis. Less than 5% of C. albicans and/or C. glabrata isolates presented low susceptibility to the drug (CMI 80 > 2.50 microg/ml). Fluconazole was less active against C. glabrata and C. krusei (CMI 80 > 100 microg/ml). The susceptibility profile for fluconazole indicated the importance to the treatment of identification to species level. |
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