The relationship between mutagenicity and carcinogenicity of some nitrosamines. |
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| Authors: | A W Andrews L H Thibault W Lijinsky |
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| Affiliation: | Chemical Carcinogenesis Program, Frederick Center Research Center, Frederick, MD 21701, U.S.A. |
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| Abstract: | The carcinogenicity and mutagenicity of 26 nitrosamines were compared to help validate the predictability of a short-term in vitro test. 80% of the compounds showed agreement between the two characteristics, while 20% did not. Of the latter group, 8% were false positives and 12% were false negatives. |
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