Model of the haemodynamic reactions to intermittent coronary sinus occlusion |
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| Institution: | 1. Department of Medicine, Peter Munk Cardiac Centre, University of Toronto, Toronto, Ontario, Canada;2. Department of Medicine, Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, California, USA;3. Department of Cardiac Sciences, Section of Cardiac Surgery, Cumming School of Medicine, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada;4. Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada;5. Department of Medicine, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts and Baim Institute for Clinical Research, Brookline, Massachusetts, USA;6. British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, UK;7. Department of Surgery, Peter Munk Cardiac Centre, University of Toronto, Toronto, Ontario, Canada;8. Department of Surgery, Cumming School of Medicine, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada;9. Department of Medicine, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California, USA |
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| Abstract: | Coronary sinus pressure data have been obtained from anaesthetized dogs during pressure controlled intermittent coronary sinus occlusion. It is the main aim of this paper to provide a mathematical procedure for modelling the typical time course of sinus pressure after temporary obstruction of the sinus. The model is produced by fitting a parameterized function to the systolic and diastolic pressures in order to represent mathematically the shape of the curves. The parameters characterize the rise in coronary sinus pressure following occlusion, and are used to calculate ‘derived quantities’ which mimic the physician's visual assessment of trace recordings and their clinical implications in certain forms of coronary sinus pressure reaction. This procedure should be thought of as a kind of pattern recognition which reflects the changing state of the myocardium. The mathematical results are shown to bear a close resemblance to the clinical effects of coronary sinus occlusion. |
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