Pericardial heterograft valves: An assessment of leaflet stresses and their implications for heart valve design |
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| Institution: | 1. Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands;2. Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology, Delft, The Netherlands;3. Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands;1. Department of Laboratory Medicine, Karolinska Institutet, Huddinge SE-141 86, Sweden;2. Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå SE-901 87, Sweden;1. Institute of Physics of the Dagestan Scientific Center of the Russian Academy of Sciences, Makhachkala, Dagestan, Russian Federation;2. Thermodynamics Research Center, Applied Chemicals and Materials Division (647), Material Measurement Laboratory, National Institute of Standards and Technology, 325 Broadway, Boulder, CO 80305-3337, USA;3. Dagestan State University, Makhachkala, Dagestan, Russian Federation;4. Geothermal Research Institute of the Russian Academy of Sciences, Makhachkala, Dagestan, Russian Federation;1. Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, 39 East Beijing Road, Nanjing 210008, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;3. State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, 39 East Beijing Road, Nanjing 210008, PR China;4. Key Laboratory of Economic Stratigraphy and Palaeogeography, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, 39 East Beijing Road, Nanjing 210008, PR China |
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| Abstract: | Bovine pericardium, stabilized with glutaraldehyde, is used widely in the construction of heart valve substitutes, but the design and construction of valve substitutes from this material are empirically based. Collagenous tissue can support tension, but experimental evidence indicates that flexure-induced compressive stresses can lead to fatigue failure. This study uses experimental results obtained from cyclic uniaxial load tests to predict the type and magnitude of operational stresses which occur in pericardial heterograft leaflets. Both Young's modulus and Poisson's ratio varied with uniaxial loading in pericardium, chemically modified free of tension. Leaflet stresses were analysed by using effective incremental representations of these parameters. In leaflets with unrestricted rotation at the point of attachment to the stent, the mid-plane tensions always exceeded the bending stresses, and no zones of leaflet compression were predicted. In contrast, with totally restricted leaflet rotation induced by clamping (possibly between a male and female frame) the bending stresses were greater than the mid-plane tensions at the hinge line and significant compressive stresses were predicted at this site. If elastic boundary conditions were introduced at the stent (possibly by wrapping the stent in pericardium) then the compressive stresses were reduced as the degree of elasticity was increased. Glutaraldehyde fixation of the pericardium under load produced a stiffer material; higher compressive stresses at the stent and significant increases in total stress were predicted for this tissue. The application of elevated pressure loading also increased the compressive and total stresses in the leaflet. Finally, it was shown that bicuspid leaflets were likely to experience higher stresses than tricuspid leaflets. This simple stress analysis should help valve designers of pericardial heterografts to identify those conditions which lead to tissue compression, high total stress, and ultimately material fatigue. |
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