Cell immobilization: Application to alcohol production |
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| Institution: | 1. Department of Occupational and Environmental Health, School of Public Health, Nantong University, Nantong, Jiangsu, China;2. Department of Prevention and Control for Occupational Disease, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China;3. School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China;4. Kunshan Municipal Center for Disease Prevention and Control, Kunshan, Jiangsu, China;5. Department of Public Health Sciences, University of North Carolina Charlotte, Charlotte, NC, USA;6. Department of Emergency Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China;7. Department of Pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou, Jiangsu, China;1. 24 rue Gauthey, F-75017 Paris, France;2. Lebanese University, Faculty of Sciences II, Department of Natural Sciences, Fanar, Fanar – Matn – P.O. Box 26110217, Lebanon;3. Muséum National d''Histoire Naturelle, Institut de Systématique, Evolution, Biodiversité, ISYEB, UMR 7205 CNRS UPMC EPHE, CP50, 45 rue Buffon, F-75005 Paris, France;1. Faculty of Chemistry, University of Warsaw, ul. Pasteura 1, PL-02-093 Warsaw;2. Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, ul. Zwirki i Wigury 101, PL-02-093 Warsaw |
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| Abstract: | The immobilization of whole cells is a technique that can be used in several production processes, among them alcoholic fermentation. By concentrating an active cell biomass in a bioreactor, the efficiency of bioconversion increases, as does the reactor productivity which, in turn, results in the reduction of the reactor size for a given production rate. Immobilization can be carried out in different ways; adsorption and entrapment in gelatinous matrices are the methods most commonly used. These techniques can be applied to practically all of the viable and non-viable whole cells systems of interest. Several reactor configurations are used sucessfully; many more have been proposed. Fermentor design imposes limitations on immobilization processes, requiring study of such aspects as mass-transfer, growth of cells in the reactor, aeration and backmixing. |
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