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Interaction energy studies of pyrazolopyrimidine antibiotics during transcription: formycin B |
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| Affiliation: | 1. Department of Medicine, University of Tsukuba, Tsukuba 305-8577, Japan;2. Division for Therapies Against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan;3. College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China;4. National Institute of Crop Science, National Agriculture and Food Research Organization, Tsukuba 305-8518, Japan |
| Abstract: | The interaction energies of various type of binding pattern of pyrazolopyrimidine antibiotics formycin B (laurusin) with nucleic acid fragments (bases and base pairs) have been computed and compared with the corresponding binding energy for normal bases. These results are discussed in the light of the incorporation model to explain the biological function of formycin B. These findings are in agreement with the experimentally observed evidence. |
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