The role of ubiquitination and deubiquitination in tumor invasion and metastasis |
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| Authors: | Shuangze Han Ruike Wang Yangnan Zhang Xiaoying Li Yu Gan Feng Gao Pengfei Rong Wei Wang Wei Li |
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| Institution: | 1.Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China;2.Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China;3.Department of Ultrasonography, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China |
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| Abstract: | Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival. Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent roles in modulating tumor metastasis. This review will briefly summarize the observations and underlying mechanisms of multiple E3 ubiquitin ligases and deubiquitinases to regulate tumor metastasis. Further, we will discuss the relationship and importance between ubiquitination components and tumor progression. |
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| Keywords: | ubiquitination E3 ubiquitin ligase deubiquitinase metastasis |
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