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The aromatase inhibitor 4-hydroxyandrostenedione inhibits the formation of 19-norandrostenedione by porcine grakulosa cells in vitro {Poster 32} |
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| Authors: | M.W. Khalil P. Morley M.A. Glasier D.T. Armstrong |
| Affiliation: | a MRC Group in Reproductive Biology, and Department of obstetrics, Gynecology, University of Western Ontario, London, Ontario, N6A 5A5, Canada b MRC Group in Reproductive Biology, and Department of Biochemistry, University of Western Ontario, London, Ontario, N6A 5A5, Canada c MRC Group in Reproductive Biology, and Department of Physiology, University of Western Ontario, London, Ontario, N6A 5A5, Canada |
| Abstract: | Porcine granulosa cells convert androstenedione (A) to 19-norandrostenedione (19-norA) and 19-hydroxyandrostenedione (19-OHA) in the presence of FSH and 10% porcine serum; 19-norA is also formed from independent incubations with 19-OHA. 19-NorA and 19-OHA formation from A, and 19-norA from 19-OHA, is blocked by 4-hydroxyandrostenedione, an irreversible inhibitor of aromatase. |
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