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Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening |
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| Authors: | Konstantin Schneider Jens Olaf Krömer Christoph Wittmann Isabel Alves-Rodrigues Andreas Meyerhans Juana Diez Elmar Heinzle |
| Institution: | 1. Biochemical Engineering Institute, Saarland University, 66123, Saarbrucken, Germany 4. Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Australia 5. Biochemical Engineering Institute, Technische Universit?t Braunschweig, Braunschweig, Germany 3. Department of Experimental and Health Sciences, University Pompeu Fabra, 08003, Barcelona, Spain 2. Institute of Virology, Saarland University, 66421, Homburg, Germany |
| Abstract: | BackgroundThe cellular proteins Pat1p, Lsm1p, and Dhh1p are required for the replication of some positive-strand viruses and therefore are potential targets for new antiviral drugs. To prioritize host targets for antiviral drug screening a comparative metabolome analysis in Saccharomyces cerevisiae reference strain BY4742 Matα his3Δ1 leu2Δ0 lys2Δ0 ura3Δ0 and deletion strains pat1Δ, lsm1Δ and dhh1Δ was performed. |
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