Defective thymine dimer excision in radiation-sensitive mutants rad10 and rad16 of Saccharomyces cerevisiae |
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| Authors: | Louise Prakash |
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| Institution: | (1) Department of Radiation Biology and Biophysics, School of Medicine and Dentistry, University of Rochester, 14642 Rochester, New York, USA |
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| Abstract: | Summary Two rad mutants of yeast, rad10 and rad16, are shown to be defective in the removal of UV-induced pyrimidine dimers since DNAs obtained from irradiated cells following a post-irradiation incubation in the dark still retain UV-endonuclease-sensitive sites. Both rad10 and rad16 mutants are in the same pathway of excision-repair as the rad1, rad2, rad3 and rad4 mutants. |
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