Dexamethasone partially reduces and 2% saline-treatment abolished electroacupunture analgesia: these findings implicate pituitary endorphins. |
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| Authors: | R Cheng B Pomeranz G Yü |
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| Institution: | Department of Zoology, University of Toronto, Toronto, Ontario, Canada, M5S 1A1 |
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| Abstract: | Dexamethasone, a cortisol analogue which inhibits ACTH and endorphin release in a negative feedback system, partially reduces electroacupuncture analgesia (EAA) in mice. In addition, mice forced to drink 2% saline for 3 days (this reduces pituitary endorphin levels) had a complete loss of EAA. These two experiments support our previous finding that hypophysectomy abolishes EAA. Altogether, these results implicate pituitary endorphins in EAA. |
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