Binding of aminoglycoside antibiotics with modified A-site 16S rRNA construct containing non-nucleotide linkers |
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| Authors: | Tok Jeffrey B-H Wong Wilson Baboolal Nyla |
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| Affiliation: | Department of Chemistry & Natural Sciences, York College and Graduate Center of the City University of New York, 94-20 Guy R. Brewer Blvd., Jamaica, NY 11451, USA. tok@york.cuny.edu |
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| Abstract: | The design and synthesis of synthetically modified cyclic A-site 16S rRNA construct is reported. The binding characteristics of several members of the aminoglycoside antibiotics with this novel class of synthetically modified A-site 16S rRNA constructs were subsequently investigated. |
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