Canonical Wnt signaling: an unexpected new player |
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| Authors: | Habas Raymond |
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| Affiliation: | Department of Biochemistry, UMDNJ-Robert Wood Johnson Medical School and The Cancer Institute of New Jersey, Piscataway, New Jersey 08854, USA. |
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| Abstract: | Canonical Wnt signaling, below the Fz/LRP receptor complex, induces the stabilization of beta-catenin via an unresolved mechanism. A recent study in Genes & Development introduces a new player and deepens our understanding of this signaling relay that plays pivotal roles during embryogenesis and tumorigenesis. |
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