Isolation and characterization of hemolysin mutants of Vibrio vulnificus |
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| Authors: | George Massad Linda M. Simpson J.D. Oliver |
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| Affiliation: | Department of Microbiology, University of Mississippi Medical Center, Jackson, Mississippi, U.S.A.;Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina, U.S.A. |
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| Abstract: | Abstract The importance of the cytolysin/hemolysin in the virulence of Vibrio vulnificus was investigated using both the naturally occuring virulent and avirulent colony variants and ethylmethane-sulfonate generated mutants. Both virulent and avirulent isogenic morphotypes produced similar amounts of hemolysin. Two mutants deficient in the production of hemolysin and negative for CHO cell activity were characterized and their virulence for mice was examined. Non-hemolytic mutants were found to be as virulent as their parent strain. It is concluded that the hemolysin produced by V. vulnificus is not required for the full virulence of this pathogen. |
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| Keywords: | Cytotoxin Virulence Vibrio vulnificus |
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