Testing of a monogenic hypothesis in pedigrees of an arbitrary structure selected for a proband. III. Quantitative traits

Methods of the Mendelian analysis of quantitative characters by pedigrees selected for proband are discussed. The method is illustrated on the example of the familial hypercholesterinemia in man. The estimations of parameters of monogenic hypothesis of inheritance, obtained by the maximum likelihood method, are considered, their adequacy discussed, and prognostic criteria of fitness of the genetic hypothesis introduced.