| Abstract: | The authors reported previously an elementary mathematical model of intracranial pressure (ICP) as well as result from an experimental verification of the model. The experimental tests revealed that certain factors had been neglected in the theoretical formation, and the present article offers an expanded version of model which takes into account those factors: changes in the formation of the CSF as a function of ICP; cerebral vasomotricity; cortical and sinusal venous pressures, and variations of the filtration coefficient of the subarachnoidal spaces. A generalized mathematical model of ICP, in the form of four equations, is proposed. The major aspects of both normal and pathological ICP are studied in the light of this model, and are integrated into a generalized theory. |
