A convenient solid-phase method for the synthesis of novel oligonucleotide-folate conjugates |
| |
| Authors: | Kazanova Eugenia V Zubin Eugeny M Kachalova Anna V Volkov Eugeny M Oretskaya Tatiana S Stetsenko Dmitry A Gottikh Marina B |
| |
| Institution: | Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonossov Moscow State University, Moscow, Russia. |
| |
| Abstract: | We describe the preparation of two batches of a polymer support for the incorporation of folic acid into oligonucleotides. The method permits the regioselective attachment of a target nucleic acid sequence through its 3'-end to either the alpha-or gamma-carboxyl group of L-glutamic acid, respectively. The supports have been tested in solid-phase synthesis of oligonucleotide-folate conjugates for cell delivery studies. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
