Identification of a siderophore utilization locus in nontypeable <Emphasis Type="Italic">Haemophilus influenzae</Emphasis> |
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| Authors: | Daniel J Morton Elizabeth J Turman Patrick D Hensley Timothy M VanWagoner Thomas W Seale Paul W Whitby Terrence L Stull |
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| Institution: | (1) Department of Pediatrics, University of Oklahoma Health Sciences Center, 73104 Oklahoma City, OK, USA;(2) Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 73104 Oklahoma City, OK, USA;(3) Department of Biology, Oklahoma Christian University, 73136 Oklahoma City, OK, USA |
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| Abstract: | Background
Haemophilus influenzae has an absolute aerobic growth requirement for either heme, or iron in the presence of protoporphyrin IX. Both iron and heme
in the mammalian host are strictly limited in their availability to invading microorganisms. Many bacterial species overcome
iron limitation in their environment by the synthesis and secretion of small iron binding molecules termed siderophores, which
bind iron and deliver it into the bacterial cell via specific siderophore receptor proteins on the bacterial cell surface.
There are currently no reports of siderophore production or utilization by H. influenzae. |
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