| 适体酶Aptazymes的研究进展 |
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| 引用本文： | 曾燕丽,兰小鹏. 适体酶Aptazymes的研究进展[J]. 生物化学与生物物理进展, 2007, 34(6): 567-572 |
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| 作者姓名： | 曾燕丽 兰小鹏 |
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| 作者单位： | 福建医科大学临床教学基地福州总医院全军医学检验研究所,福州,350025 |
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| 基金项目： | 全军医学科学技术研究计划 |
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| 摘 要： | 适体酶是从寡核苷酸随机序列库中筛选获得的针对各种效应分子的一种新的人工合成酶.它具有适体的特异性和核酶的催化活性.适体酶作为催化分子信标,为效应分子的定量分析提供了新的思路.适体酶不仅在基因组学和蛋白质组学中应用,而且在生物传感器和DNA分子逻辑研究中具有潜在的应用前景.
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| 关 键 词： | 适体酶 别构效应核酶 别构效应脱氧核酶 别构筛选 催化分子信标 逻辑门 |
| 收稿时间： | 2006-11-20 |
| 修稿时间： | 2006-11-21 |
Progress in Aptazymes |
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| ZENG Yan-Li and LAN Xiao-Peng. Progress in Aptazymes[J]. Progress In Biochemistry and Biophysics, 2007, 34(6): 567-572 |
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| Authors: | ZENG Yan-Li and LAN Xiao-Peng |
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| Affiliation: | People's Liberation Army Center of Laboratory Medicine, Fuzhou General Hospital, Clinical Medicine School of Fujian Medical University, Fuzhou 350025, China;People's Liberation Army Center of Laboratory Medicine, Fuzhou General Hospital, Clinical Medicine School of Fujian Medical University, Fuzhou 350025, China |
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| Abstract: | Aptazymes are a new artificial synzyme, selected from the random oligonucleotide sequence libraries against various of effector molecules. They own the advantages of an aptamer(the receptor site) and the ribozyme (the catalytic active site). Moreover, aptazymes as catalytic molecular beacon provide a new orientation for the quantitative analysis of effector molecules. Aptazymes not only have the application in genomics and proteomics, but also have potential applications in biosensor and DNA AND gate. |
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| Keywords: | aptazymes allosteric ribozymes allosteric deoxyribozymes allosteric selection catalytic molecular beacon AND gate |
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