Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging beta-amyloid in Alzheimer's disease |
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| Authors: | Zeng Fanxing Southerland Jeanine A Voll Ronald J Votaw John R Williams Larry Ciliax Brian J Levey Allan I Goodman Mark M |
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| Affiliation: | Department of Radiology, Division of Radiological Sciences, Emory University, Atlanta, GA 30322, USA. |
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| Abstract: | Two new fluorinated imidazo[1,2-a]pyridine derivatives, 6-(2'-fluoroethyl)-2-(4'-dimethylamino)phenylimidazo[1,2-a]pyridine (FEPIP) and 6-(3'-fluoropropyl)-2-(4'-dimethylamino)phenylimidazo[1,2-a]pyridine (FPPIP), were synthesized. The binding affinity for FEPIP and FPPIP to amyloid plaques in human AD cortical tissues was determined. Radiolabeling, in vitro film autoradiography, and micro-PET study were performed with [18F]FPPIP to determine its utility as a radioligand for amyloid plaque imaging in the brain of AD patients. |
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