Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei |
| |
Authors: | Wang Mi Qanungo Suparna Crow Michael T Watanabe Michiko Nieminen Anna-Liisa |
| |
Institution: | Department of Anatomy and Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. |
| |
Abstract: | Apoptosis repressor with caspase recruitment domain is expressed at high levels in brain and myogenic tissues, consistent with a role to inhibit apoptosis in the terminally differentiated cells. Expression of ARC in cancers is not known. In this study, we reported that ARC was highly expressed in various non-myogenic and non-neurogenic human and rat cancer cell lines. Unexpectedly, ARC was localized almost exclusively to the nuclei of cancer cells, which was unlike the cytoplasmic localization of ARC in non-cancer cells. Furthermore, nuclear ARC in cancer cells did not co-localize with nucleolus protein of 30 kDa, an alternatively spliced ARC isoform. These findings indicate that ARC is distributed differently in cancer cells than non-cancer cells and thus might play a role in neoplastic transformation. |
| |
Keywords: | ARC apoptosis repressor with CARD domain CARD caspase recruitment domain CK2 casein kinase II Nop30 nucleolus protein of 30 kDa NQO-1 NAD(P)H:quinone oxidoreductase 1 NLS nuclear localization signal YY-1 YinYang 1 |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|