Effects of haloperidol and clotrimazole on synaptic transmission in and contractile activity of smooth muscles of the guinea-pig intestine |
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Authors: | A V Romanenko M M Grusha |
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Institution: | (1) Ministry of Public Health of Ukraine, Bogomolets National Medical University, Kyiv, Ukraine |
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Abstract: | In muscle strips of the guinea-pig large intestine, haloperidol and clotrimazole increased spontaneous electrical and contractile
activities and decreased ATP-evoked hyperpolarization of smooth-muscle cells and the amplitude of inhibitory synaptic potentials.
The pattern of effects of haloperidol on hyperpolarization induced by intramural stimulation of muscle strips was preserved
under conditions of pre-incubation of the preparations in Krebs solutions containing pyridoxal-5′-phosphate, Nω-nitro-L-arginine,
or apamin, as well as both apamin and tetraethylammonium.
Neirofiziologiya/Neurophysiology, Vol. 39, Nos. 4/5, pp. 412–415, July–October, 2007. |
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Keywords: | intestinal smooth muscles haloperidol clotrimazole |
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