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Synthesis, structure, and pharmacological activity of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid |
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| Authors: | O B Kazakova I E Smirnova H Do Tkhi Tkhu Tkhankh Tra Nguen G N Apryshko O S Zhukova N I Medvedeva T I Nazyrov E V Tret’yakova I V Chudov A F Ismagilova K Yu Suponitsky D V Kazakov F E Safarov G A Tolstikov |
| Institution: | 16461. Institute of Organic Chemistry, Ufa Scientific Centre, Russian Academy of Sciences, pr. Oktyabrya, 71, Ufa, 450054, Russia 26461. Institute of Chemistry, Vietnam Academy of Sciences and Technology, Khoang Quoc Viet, 18, Cau Giay, Hanoi, Vietnam 36461. Blokhin Russian Cancer Research Centre, Moscow, Russia 46461. Bashkir State Agrarian University, Ufa, Russia 56461. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia |
| Abstract: | The synthesis of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid was carried out and its structure was established by X-ray diffraction. The antineoplastic activity and the ability to induce apoptosis that were predicted by a PASS computer system, correlate well with the experimentally found cytotoxic activity towards the MeWo malignant cell line. The results of tests on animals showed that abietic acid and its (7R,8S)-epoxy-(13R,17R)-trioxolane derivative have anti-inflammatory and antiulcer activities in the absence of side effects. |
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