Vitamin K dependent carboxylation: study of diastereoisomeric gamma-methylglutamic acid containing peptidic substrates |
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| Authors: | M Gaudry S Bory J Dubois R Azerad A Marquet |
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| Affiliation: | 1. Laboratoire de Chimie Organique Biologique, ERA 823, Université P. & M. Curie, 4 place Jussieu, 75230 Paris Cedex 05, France;2. Institut de Biochimie, Université Paris Sud, 91405 Orsay Cedex France |
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| Abstract: | Two pentapeptides Phe-Leu-X-Glu-Val where X is either the L-threo-gamma-methylglutamic acid or the L-erythro isomer have been synthesized and tested as substrates in the vitamin K dependent carboxylation. The gamma-methylglutamic residue is not carboxylated and both peptides are inhibitors of the carboxylation of the reference peptide Phe-Leu-Glu-Glu-Val. The threo containing isomer has a much better affinity than the reference and is the best inhibitor of this reaction described so far. |
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