Cytological analyses of a 14p+variant by means of N-banding and combinations of silver staining and chromosome bandings |
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| Authors: | Y. F. Lau W. Wertelecki R. A. Pfeiffer F. E. Arrighi |
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| Affiliation: | (1) Section of Cell Biology, The University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute, 77030 Houston, Texas, USA;(2) The Graduate School of Biomedical Sciences, The University of Texas Health Science Center, 77030 Texas, Houston, USA;(3) Department of Medical Genetics, College of Medicine, University of South Alabama, 36617 Mobile, Alabama, USA;(4) Institut für Humangenetik, Medizinische Hochschule Lübeck, D-2400 Lübeck, Federal Republic of Germany |
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| Abstract: | Summary An inherited human karyological variant (14p+) has been studied with a number of cytochemical techniques. The short arm of this variant chromosome 14 is nearly as long as the long arm, giving the chromosome a submetacentric to metacentric appearance. In conventionally Giemsa-stained preparations, a maximum of three secondary constrictions can be observed in the marker arm. The secondary constrictions are silver-positive in Ag-NOR preparations. However, the entire arm stains deeply in N-banded preparations. The 14p+ arm also Q-negative, C-negative, G-negative, and R-positive with an almost homogeneous texture. The difference between N-banding and silver staining is interpreted as the result of gene activities of the ribosomal cistrons. |
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