Lipid rafts as organizing platforms for cell chemotaxis and axon guidance

Lipid rafts are thought to serve as plasma membrane platforms for localized trafficking and signaling. Recent findings reported by Guirland et al. in this issue of Neuron and by Gómez-Moutón in a recent issue of JCB support a direct role of lipid microdomains in organizing spatial signaling during axon guidance and cell chemotaxis by concentrating the gradient-sensing machinery at the leading edge.