Molecular analysis of relapses or reinfections of Clostridium difficile-associated diarrhea |
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Authors: | Sisto Francesca Scaltrito Maria Maddalena Zago Miriam Bonomi Arianna Coccè Valentina Frugoni Sergio |
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Institution: | Dipartimento di Sanità Pubblica-Microbiologia-Virologia, Università degli Studi, Milano, Italy. francesca.sisto@unimi.it |
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Abstract: | Recurrence is a major complication of Clostridium difficile-associated diarrhea and occurs in 15 to 20% of patients after discontinuation of therapy. Strains from 53 patients with Clostridium difficile recurrences were fingerprinted by PCR ribotyping. Reinfection with a different strain occurred in 15 out of 53 patients (28,3%), while 38 patients relapsed. These data suggest the need to perform molecular typing for implementation of infection control procedures and for a more appropriate therapeutic strategy. |
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