Electron microscopic demonstration of a common structural motif in human complement factor C3 and rat α1 -inhibitor 3 (murinoglobulin) |
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Authors: | Atsushi Ikai Masaaki Nishigai Akio Saito Hyogo Sinohara Yutaka Muto Yoji Arata |
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Abstract: | Electron microscopy of two homologous giant proteins revealed that complement factor C3 and αi-inhibitor 3 have a common structural motif of a semicircularly bent string 18–20 nm long with two or three bumps indicating globular domains. C3 had a structure similar to the letter C with a small but distinct hole in the center. α1-Inhibitor 3 was a more complete ring sometimes ajar at one corner. When the latter was treated with a proteinase, it became slightly flattened and adopted a squarish C-shape. |
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Keywords: | Complement factor C3 α 1-Inhibitor 3 Electron micrograph Homologous protein structure |
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