| 木豆素对慢性不可预见温和应激小鼠的抗抑郁作用 |
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| 引用本文： | 张梦荻,王丽莎,李晨晨,陶雪,周云丰,刘新民,潘瑞乐,常琪.木豆素对慢性不可预见温和应激小鼠的抗抑郁作用[J].中国实验动物学报,2019(1):85-90. |
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| 作者姓名： | 张梦荻 王丽莎 李晨晨 陶雪 周云丰 刘新民 潘瑞乐 常琪 |
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| 作者单位： | 中国医学科学院北京协和医学院药用植物研究所;中国航天员科研训练中心人因工程重点实验室 |
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| 基金项目： | 中国医学科学院创新工程:中药资源可持续利用关键技术和新药研发(2016-I2M-1-012)~~ |
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| 摘 要： | 目的观察木豆素于抗抑郁方面的作用,并初步探讨其可能的作用机制。方法采用小鼠慢性不可预见温和应激模型(chronic unpredictable mild stress,CUMS),进行糖水偏好实验评价经木豆素处理的小鼠的快感缺失情况,采用酶联免疫吸附测定法测定小鼠血清皮质酮的含量,采用LC-MS/MS法检测小鼠皮层和海马中多种神经递质的含量。结果木豆素可以逆转CUMS引起的糖水偏爱指数降低和血清皮质酮水平升高。并且与正常组相比,模型组小鼠皮层和海马中相关神经递质的含量发生了显著的改变,而木豆素给药对于CUMS小鼠体内相关神经递质具有明显的调节作用。结论木豆素可能通过降低血清皮质酮水平和调节脑内神经递质来实现抗抑郁作用。
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| 关 键 词： | 木豆素 抗抑郁 慢性不可预见应激 皮质酮 神经递质 |
Antidepressant effects of cajaninstilbene acid on chronic unpredictable mild stress-induced depressive mice |
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| ZHANG Mengdi,WANG Lisha,LI Chenchen,TAO Xue,ZHOU Yunfeng,LIU Xinmin,PAN Ruile,CHANG Qi.Antidepressant effects of cajaninstilbene acid on chronic unpredictable mild stress-induced depressive mice[J].Acta Laboratorium Animalis Scientia Sinica,2019(1):85-90. |
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| Authors: | ZHANG Mengdi WANG Lisha LI Chenchen TAO Xue ZHOU Yunfeng LIU Xinmin PAN Ruile CHANG Qi |
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| Institution: | (Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193, China;National Key Laboratory of Human Factors Engineering and the State Key Laboratory ofSpace Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094) |
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| Abstract: | ZHANG Mengdi;WANG Lisha;LI Chenchen;TAO Xue;ZHOU Yunfeng;LIU Xinmin;PAN Ruile;CHANG Qi(Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193, China;National Key Laboratory of Human Factors Engineering and the State Key Laboratory ofSpace Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094) |
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| Keywords: | cajaninstilbene acid antidepressant chronic unpredictable mild stress corticosterone neurotransmitters mouse |
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