Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells |
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Authors: | Tetsuya Tsuji Shinji Takeoka Yosuke Okamura Ryo Sudo Yasuo Ikeda Kazuo Tanishita |
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Institution: | (1) Department of System Design Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-Ku, Yokohama 223-8522, Japan;(2) Department of Polymer Chemistry, Waseda University, 3-4-1 Ohkubo, Shinjyuku-ku, Tokyo 169-8555, Japan;(3) Department of Biological Engineering, MIT, Cambridge, MA, USA;(4) School of Medicine, Keio University, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan |
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Abstract: | Polymerized albumin particles (poly Alb) with recombinant glycoprotein Ibα (rGPIbα-poly Alb) are a promising candidate for
a platelet substitute. Thus, we focused on the lateral motion of poly Alb in the presence of red blood cells, because the
lateral motion plays an important role in aggregate formation. We visualized the microscopic motion of poly Alb toward the
immobilized ligand (von Willebrand factor, VWF) surface in a model arteriole with red blood cells with a high-speed camera.
At a higher shear rate of 1,500 s−1, the concentration profile of poly Alb appeared to peak near the wall. This profile enhances the interaction between the
particles and wall. Particularly the migration angle, being the angle of the poly Alb velocity vector, was enlarged near the
wall and contributed to transfer of poly Alb toward the immobilized VWF surface. This tendency is desirable to achieve the
adhesion of particles on the wall. |
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Keywords: | Platelet substitute Von Willebrand factor Polymerized albumin particles Lateral motion |
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