Glucagon-like peptides 1 and 2 in health and disease: A review |
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| Institution: | 1. Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA;2. Center for Translational Neuroscience, College of Medicine, University of Missouri, Columbia, MO 65211, USA;3. Department of Chemistry, University of Missouri, Columbia, MO 65211, USA;4. Research Reactor Center, University of Missouri, Columbia, MO 65211, USA;5. Research Service, Harry S. Truman Memorial Veterans'' Hospital, Columbia, MO 65201, USA;6. Department of Radiology, University of Missouri, Columbia, MO 65211, USA |
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| Abstract: | The gut derived peptides, glucagon-like peptides 1 and 2 (GLP-1 and GLP-2), are secreted following nutrient ingestion. GLP-1 and another gut peptide, glucose-dependent insulinotropic polypeptide (GIP) are collectively referred to as ‘incretin’ hormones, and play an important role in glucose homeostasis. Incretin secretion shares a complex interdependent relationship with both postprandial glycemia and the rate of gastric emptying. GLP-1 based therapies are now well established in the management of type 2 diabetes, while recent literature has suggested potential applications to treat obesity and protect against cardiovascular and neurological disease. The mechanism of action of GLP-2 is not well understood, but it shows promise as an intestinotropic agent. |
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