The interface of hypothalamic–pituitary–adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress |
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| Institution: | 1. Health Unit, Flemish Institute for Technological Research (VITO), Mol, Belgium;2. Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium;3. Transportation Research Institute, Hasselt University, Hasselt, Belgium;4. Revalidatie- en gezondheidscentrum, Jessa Hospital, Hasselt, Belgium;5. Otto Loewi Research Center of Vascular Biology, Immunity and Inflammation, Medical University Graz, Graz, Austria;6. Department of Public Health & Primary Care, Leuven University, Leuven, Belgium;7. Faculty of Medicine and Life Sciences Hasselt University, Hasselt, Belgium;1. Univ. Grenoble Alpes, HP2, F-38000 Grenoble, France;2. INSERM U1042, HP2, F-38000 Grenoble, France;3. CHU de Grenoble, Cardiovascular & Thoracic Unit; Sports & Pathologies, F-38000 Grenoble, France;1. Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia;2. School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia;3. School of Women''s and Infants'' Health, University of Western Australia, Crawley, Australia;4. School of Population Health, University of Western Australia, Crawley, Australia;5. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada |
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| Abstract: | Brain natriuretic peptide (NT-pro-BNP) was implicated in the regulation of hypothalamic–pituitary–adrenocortical (HPA) responses to psychological stressors. However, HPA axis activation in different physical stress models and its interface with NT-pro-BNP in the prediction of cardiopulmonary performance is unclear. Cardiopulmonary test on a treadmill was used to assess cardiopulmonary parameters in 16 elite male wrestlers (W), 21 water polo player (WP) and 20 sedentary age-matched subjects (C). Plasma levels of NT-pro-BNP, cortisol and adrenocorticotropic hormone (ACTH) were measured using immunoassay sandwich technique, radioimmunoassay and radioimmunometric techniques, respectively, 10 min before test (1), at beginning (2), at maximal effort (3), at 3rd min of recovery (4). In all groups, NT-pro-BNP decreased between 1 and 2; increased from 2 to 3; and remained unchanged until 4. ACTH increased from 1 to 4, whereas cortisol increased from 1 to 3 and stayed elevated at 4. In all groups together, ΔNT-pro-BNP2/1 predicted peak oxygen consumption (B = 37.40, r = 0.38, p = 0.007); cortisol at 3 predicted heart rate increase between 2 and 3 (r = ?0.38,B = ?0.06, p = 0.005); cortisol at 2 predicted peak carbon-dioxide output (B = 2.27, r = 0.35, p < 0.001); ΔACTH3/2 predicted peak ventilatory equivalent for carbon-dioxide (B = 0.03, r = 0.33, p = 0.003). The relation of cortisol at 1 with NT-pro-BNP at 1 and 3 was demonstrated using logistic function in all the participants together (for 1/cortisol at 1 B = 63.40, 58.52; r = 0.41, 0.34; p = 0.003, 0.013, respectively). ΔNT-pro-BNP2/1 linearly correlated with ΔACTH4/3 in WP and W (r = ?0.45, ?0.48; p = 0.04, 0.04, respectively). These results demonstrate for the first time that HPA axis and NT-pro-BNP interface in physical stress probably contribute to integrative regulation of cardiopulmonary performance. |
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| Keywords: | Brain natriuretic peptide Cortisol Adrenocorticotropic hormone Hypothalamic–pituitary–adrenocortical axis Cardiopulmonary test Stress axis |
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