Regulation of feeding behavior,gastrointestinal function and fluid homeostasis by apelin |
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| Affiliation: | 1. Department of Energy and Resources Engineering, College of Engineering, Peking University, Beijing 100871, China;2. Beijing Key Laboratory for Solid Waste Utilization and Management, Peking University, Beijing 100871, China;1. China Academy of Chinese Medical Sciences, Institute of Acupuncture and Moxibustion, Beijing 100700, China (中国中医科学院针灸研究所, 北京100700, 中国);2. Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China (中国中医科学院望京医院, 北京100102, 中国);3. Guang''anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China (中国中医科学院广安门医院, 北京100053, 中国);4. Hubei University of Chinese Medicine, Wuhan 430061, China (湖北中医药大学, 武汉430061,中国);5. North China University of Science and Technology, Tangshan 063210, Hebei, China (华北理工大学, 河北唐山063210, 中国) |
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| Abstract: | Apelin was first identified and characterized from bovine stomach extracts as an endogenous ligand for the APJ receptor. Apelin/APJ system is abundantly present in peripheral tissues and central nervous system. Apelin plays a broad role in regulating physiological and pathological functions. Recently, many reports have showed the effects of apelin on feeding behavior, however the results are inconsistent, due to different administration routes, animal species, forms of apelin, etc. Apelin has been involved in stimulating gastric cell proliferation, cholecystokinin (CCK) secretion, histamine release, gastric acid and bicarbonate secretion, and regulation of gastrointestinal motility. In addition, apelin produced regulatory effects on drinking behavior, diuresis, arginine vasopressin (AVP) release and glucocorticoids secretion. This article reviews the role of apelin on feeding behavior, gastrointestinal function and fluid homeostasis. |
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| Keywords: | Apelin APJ Feeding behavior Fluid homeostasis Gastrointestinal function |
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